Resources

Human Tissue, Tumor, and Cell Lines
Antibody Bank

Human Tissue, Tumor, and Cell Lines

PhenoPath Laboratories maintains a comprehensive bank of normal human tissues, human tumors, and cell lines that can be used for immunohistochemical or in situ hybridization studies.

Both frozen and formalin-fixed, paraffin embedded tissues are available, covering a wide range of normal tissues including but not limited to: Adrenal, Blood vessels, Bone marrow, Brain, Breast, Cervix, Esophagus, Eye, Fallopian tube, Heart, Small and Large intestine, Kidney, Liver, Lung, Lymph node, Ovary, Pancreas, Peripheral nerve, Pituitary, Placenta, Prostate, Salivary gland, Skin, and Uterus.

Tumors include but are not limited to: Breast, Ovarian, Renal cell, Lung, Prostate, Neuroendocrine (small cell), Colonic, and Pancreatic carcinomas, Sarcomas, Melanomas, Brain and Hematopoietic neoplasms. All of the tumors have diagnoses validated by pathologists. The tissues contain a spectrum of histology and tumor grading.


Colonic adenocarcinoma with adjacent normal epithelium	Tissue microarray showing a subset of numerous breast carcinomas present on an individual slide

Our bank of tissue microarrays is continually expanding. Examples of individual arrays include samples from multiple patients with tumors such as Breast, Lung, Prostate, Colon, Ovary, Stomach, Thyroid, Liver, Kidney, Skin, Bladder, and Testis. The laboratory can also prepare specialized microarrays for individual projects. These slides can provide rapid screening of a large number of tumors in a single experiment.

Antibody Bank

Our antibody collection includes a significant bank of well-characterized monoclonal and polyclonal antibodies used in the diagnosis of human pathology, with special emphasis on the differential diagnosis of tumors. These include antibodies that identify the pathway of cell differentiation (sometimes referred to as identifying the 'cell of origin') as well as define cellular alterations at the molecular level. We also have worked with antibodies that react with molecules involved in signal transduction such as tyrosine kinases and their phosphorylated targets ( i.e. p-AKT, p-STAT 3, p-EGFR, p-met, etc.). Our antibody collection is continually expanding to include many antibodies not routinely used in the clinical laboratory, many of which identify newly described molecules involved in the pathogenesis of disease. Contact us for an updated list.


Cleaved caspase-3 nuclear staining in lymphoid tissue	Xenograft demonstrating a membranous staining pattern with c-Met