PhenoPath Physicians & Scientists

Allen M. Gown, M.D. | Lynn Goldstein, M.D. | Todd S. Barry, M.D., Ph.D. |
Patricia Kandalaft, M.D.| Steven J. Kussick, M.D., Ph.D. | Christopher Tse, MBBS| Sandeep Mukherjee, Ph.D.

Allen M. Gown, M.D. Medical Director and Chief Pathologist	Dr. Gown is a pathologist-scientist recognized as one of the world’s leading experts in the diagnostic and research applications of immunohistochemistry (IHC). He has developed numerous clinically important monoclonal antibodies used around the world (e.g., HMB-45, 34βE12, HHF35, OSCAR), and continues to be at the forefront of clinical investigative studies employing IHC and other modalities, publishing widely and presenting at national and international conferences. Dr. Gown is a member of the editorial boards of many of the major pathology journals. He is a Clinical Professor of Pathology at the University of British Columbia, Vancouver, BC, and an Affiliate Investigator in the Clinical Research Division of the Fred Hutchinson Cancer Research Center, Seattle, WA. Dr. Gown has contributed extensively to the expanding horizons of immunohistochemistry with over 200 peer-reviewed publications. Dr. Gown's Publications
Lynn Goldstein, M.D. Pathologist and Internal Research and Development Program Manager	Dr. Goldstein directs the Contract Research Department, assisting investigators in the academic, biotechnology, and pharmaceutical communities in customizing clinical research studies, and helps implement internal research and development of new tests for improved clinical diagnosis and patient management. Dr. Goldstein is board-certified in Anatomic and Clinical Pathology with a special interest in cytopathology. She received her M.D. from Boston University and is a graduate of the University of Washington Pathology Training Program. She completed a postdoctoral fellowship at the Fred Hutchinson Cancer Research Center. Dr. Goldstein has 20 years of experience in clinical positions in anatomic pathology and has held senior research positions at Genetic Systems Corporation, Oncogen, and ICOS Corporation. During this time, she was responsible for developing one of the first assays for the detection of human immunodeficiency virus. She has developed numerous monoclonal antibodies currently used in testing for infectious diseases (including herpes viruses) and has published extensively in this field. Dr. Goldstein's Publications
Todd S. Barry, M.D., Ph.D. Pathologist and Director of Molecular Pathology and Hematopathology	Dr. Barry’s focus is on expanding PhenoPath’s range of molecular diagnostic and prognostic services, including the detection of proto-oncogenes, chromosomal translocations, and chromosomal gain/deletions as they relate to hematologic and non-hematologic cancers, and PCR-based studies to address T and B cell clonality. He is board-certified in Hematopathology, as well as Anatomic and Clinical Pathology. Dr. Barry received his M.D. and Ph.D. in Immunology from Duke University. He completed an Immunohistochemistry Fellowship and a Hematopathology Fellowship in the Departments of Pathology and Laboratory Medicine at the University of Washington, in addition to a two-year Hematopathology Fellowship at the National Cancer Institute. Dr. Barry's Publications
Patricia Kandalaft, M.D. Pathologist	Dr. Kandalaft has extensive experience as a pathologist, with particular expertise in immunohistochemistry. She is board-certified in Anatomic and Clinical Pathology. She received her M.D. from the University of Missouri School of Medicine, and completed her postgraduate training in Anatomic and Clinical Pathology at the University of Michigan Medical Center and the Northwestern affiliate, Evanston Hospital. Following her residency, she completed a two-year Surgical Pathology Fellowship at the City of Hope National Medical Center under the guidance of Dr. Hector Battifora. Prior to joining PhenoPath, Dr. Kandalaft worked for 10 years in large hospital-based practices in Los Angeles, and most recently at Esoterix Laboratories in Nashville, Tennessee, where she specialized in diagnostic immunohistochemistry. Dr. Kandalaft's Publications
Steven J. Kussick, M.D., Ph.D. Pathologist and Director of Flow Cytometry	Dr. Kussick has extensive experience in the use of morphologic, immunophenotypic, and molecular methods in the diagnosis of hematolymphoid neoplasms. He is board-certified in Anatomic Pathology and Hematopathology. Dr. Kussick received his M.Sc. in Medical Statistics from the London (England) School of Hygiene and Tropical Medicine, where he studied as a George C. Marshall Scholar. He received his M.D. and Ph.D. from the Medical Scientist Training Program at the University of Washington, where he also completed his Anatomic Pathology Residency and Hematopathology Fellowship. Prior to joining PhenoPath, Dr. Kussick worked for seven years as an Attending Hematopathologist and the Associate Director of Hematopathology in the Department of Laboratory Medicine at the University of Washington. Dr. Kussick has a broad research background, with over 25 peer-reviewed research publications in areas including flow cytometry, hematopathology, basic cancer biology, and chronic disease epidemiology. Dr. Kussick's Publications
Christopher Tse, MBBS Senior Scientist	Dr. Tse is a senior pathologist who has exceptional expertise in the reading and interpretation of fluorescence in situ hybridization (FISH) studies. In that capacity, Dr. Tse works closely with Dr. Todd Barry in PhenoPath’s Molecular Pathology Laboratory, participating in the development and validation of new clinical FISH assays. Dr. Tse received his Bachelor of Medicine and Bachelor of Surgery degrees from the University of Hong Kong, and underwent extensive postgraduate training in pathology at Queen Elizabeth Hospital, Hong Kong; Princess Margaret Hospital, Hong Kong; Royal Marsden Hospital, London; Royal Free Hospital, London; St. Mark’s Hospital, London; and the Western Infirmary, Glasgow, UK. He also trained in neuropathology at the Institute of Neurological Sciences, Glasgow, UK. Dr. Tse also completed an Immunohistochemistry Fellowship at PhenoPath Laboratories in 2003-4. Prior to joining PhenoPath, Dr. Tse was the Chief of the Pathology Service at the Queen Elizabeth Hospital in Hong Kong for ten years. Dr. Tse has published extensively in various areas of diagnostic pathology, including hepatitis and hepatocellular carcinoma, as well as other solid tumors. Dr. Tse's Publications
Sandeep Mukherjee, Ph.D. Clinical Molecular Biologist, Department of Molecular Pathology and Hematopathology	Dr. Mukherjee works closely with Dr. Barry to design, develop, validate and conduct new molecular assays for clinical diagnostic testing and targeted biopharmaceutical research purposes, with a focus on molecular testing involving both PCR-based and in situ hybridization techniques, including FISH, which complement the tissue-based IHC studies performed at PhenoPath Laboratories. Dr. Mukherjee received his Ph.D. in Molecular Biology from Jadavpur University, India. He completed a Fellowship in the Department of Pathobiology at the University of Washington and Seattle Biomedical Research Institute (SBRI). Prior to joining PhenoPath, Dr. Mukherjee worked in the Infectious Disease Research Institute and then SBRI (two reputable Seattle-based biomedical institutes). Dr. Mukherjee has extensive experience in molecular biology, immunology and biochemistry. Dr. Mukherjee's Publications

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Recent Publications

Dr. Gown's Recent Publications

Vang R., Gown A.M., Barry T.S., Wheeler D.T., Ronnett B.M. Ovarian atypical proliferative (borderline) mucinous tumors:  gastrointestinal and seromucinous (endocervical-like) types are immunophenotypically distinctive. Int J Gynecol Pathol 25(1):83-89, 2006.

Ng TL, Gown AM, Barry TS, Cheang MCU, Chan AKW, Turbin DA, Hsu FD, West RB, Nielsen TO. Nuclear beta-catenin in mesenchymal tumors. Modern Pathology 18:68-74, 2005.

Terry J., Barry T.S., Horsman D.F., Hsu F.D., Gown A.M., Huntsman D.G., Nielsen T.O. Fluorescence in situ hybridization for the detection of t(X;18)(p11.2;q11.2) in a synovial sarcoma tissue microarray using a breakapart-style probe. Diagn Mol Pathol 14: 77-82, 2005.

Choo J.J., Scudiere J., Bitterman P., Dickler A., Gown A.M., Zusag T. Vaginal lymphatic channel location and its implication for intracavitary brachytherapy radiation treatment. Brachytherapy 4: 236-240, 2005.

Au NH, Gown AM, Cheang M, Huntsman D, Yorida E, Elliott WM, Flint J, English J, Gilks CB, Grimes HL. P63 expression in lung carcinoma: a tissue microarray study of 408 cases. Appl Immunohistochem Mol Morphol 12: 240-247, 2004.

Hwang H, Quenneville L, Yaziji H, Gown AM. Wilms tumor gene product: sensitive and contextually specific marker of serious carcinomas of ovarian surface epithelial origin. Appl Immunohistochem Mol Morphol 12: 122-126, 2004.

Nielsen TO, Hsu FD, Jensen K, Cheang M, Karaca G, Hu Z, Hernandez-Boussard T, Livasy C, Cowan D, Dressler L, Akslen LA, Ragaz J, Gown AM, Gilks CB, van de Rijn M, Perou CM. Immunohistochemical and clinical characterization of the basal-like subtype of invasive breast carcinoma. Clin Cancer Res 10: 5367-5374, 2004.

Gown AM. Unmasking the mysteries of antigen or epitope retrieval and formalin fixation. Am J Clin Pathol 121: 172-174, 2004.

Lin BT, Gown AM. Mixed carcinoid and adenocarcinoma of the appendix: Report of 4 cases with immunohistochemical studies and a review of the literature. Appl Immunohistochem Mol Morphol 12: 271-276, 2004.

Yaziji H, Gown AM. Accuracy and precision in HER2/neu testing in breast cancer: Are we there yet? Hum Pathol 35: 143-146, 2004.

Yaziji H, Goldstein LC, Barry TS, Werling R, Hwang H, Ellis GK, Gralow JR, Livingston RB, Gown AM. HER-2 testing in breast cancer using parallel tissue-based methods. JAMA 291: 1972-1977, 2004.

Werling RW, Hwang H, Yaziji H, Gown AM. Immunohistochemical distinction of invasive from noninvasive breast lesions: a comparative study of p63 versus calponin and smooth muscle myosin heavy chain. Am J Surg Pathol 27:82-90, 2003.

Werling RW, Yaziji H, Bacchi CE, Gown AM. CDX2, a highly sensitive and specific marker of adenocarcinomas of intestinal origin: An immunohistochemical survey of 476 primary and metastatic carcinomas. Am J Surg Pathol 27:303-310, 2003.

Yaziji H, Gown AM. Immunohistochemical markers of melanocytic tumors. Int J Surg Pathol 11:11-15, 2003.

Beach R, Gown AM, De Peralta-Venturina MN, Folpe AL, Yaziji H, Salles PG, Grignon DJ, Fanger GR, Amin MB. P504S immunohistochemical detection in 405 prostatic specimens including 376 18-gauge needle biopsies. Am J Surg Pathol 26:1588-1596, 2002.

Gown AM. Genogenic immunohistochemistry: a new era in diagnostic immunohistochemistry. Current Diagnostic Pathology 8:193-200, 2002.

Yaziji H, Gown AM. Testing for HER2 in breast cancer: is fluorescence in situ hybridization superior in predicting outcome? Adv Anatom Pathol 9:338-344, 2002.

Yaziji H, Gown AM. Controversies and guidelines in tissue-based HER2 testing in breast cancer. MLO Med Lab Obs 34:12-16, 20-21, 2002.

Gown AM, Willingham MC. Improved detection of apoptotic cells in archival paraffin sections: immunohistochemistry using antibodies to cleaved caspase 3. J Histochem Cytochem 50:449-454, 2002.

Goldstein NS, Bassi D, Watts JC, Layfield L, Yaziji H, Gown AM. E-Cadherin reactivity of 95 noninvasive ductal and lobular lesions of the breast: implications for the interpretation of problematic lesions. Am J Clin Pathol 115:534-542, 2001.

Sneige N, Yaziji H, Mandavilli SR, Perez ER, Ordonex NG, Gown AM, Ayala A. Low-grade (fibromatosis-like) spindle cell carcinoma of the breast. Am J Surg Pathol 25:1009-1016, 2001.

Lehr HA, Jacobs TW, Yaziji H, Schnitt SJ, Gown AM. Quantitative evaluation of HER2 status in breast cancer by fluorescence in situ hybridization and by immunohistochemistry with image analysis. Am J Clin Pathol 115:814-822, 2001.

Agoff SN, Grieco VS, Garcia R, Gown AM. Immunohistochemical distinction of endometrial stromal sarcoma and cellular leiomyoma. Appl Immunohistochem Mol Morphol 9:164-169, 2001.

Stone CH, Lee MW, Amin MB, Yaziji H, Gown AM, Ro JY, Tetu B, Paraf F, Zarbo RJ. Renal angiomyolipoma. Arch Pathol Lab Med 125:751-758, 2001.

Goff BA, Paley PJ, Greer BE, Gown AM. Evaluation of chemoresistance markers in women with epithelial ovarian carcinoma. Gynecol Oncol 81:18-24, 2001.

Yaziji H, Gown AM. Immunohistochemical analysis of gynecologic tumors. Int J Gynecol Path 20:64-79, 2001.

Jacobs T.W., Gown A.M., Yaziji H., Barnes M.J., Schnitt S.J. HER2 protein expression in breast cancer evaluated by immunohistochemistry. A study of interlaboratory agreement. Am J Clin Pathol 113: 251-258, 2000.

Paley PJ, Goff BA, Gown AM, Greer BE, Sage EH. Alterations in SPARC and VEGF immunoreactivity in epithelial ovarian cancer. Gynecol Oncol 78:336-341, 2000.

Lehr HA, Folpe A, Yaziji H, Kommos F, Gown AM. Cytokeratin 8 immunostaining pattern and E-cadherin expression distinguishing lobular from ductal breast carcinoma. Am J Clin Pathol 114:190-196, 2000.

Yaziji H, Sneige N, Gown AM. Detection of stromal invasion in breast cancer: The myoepithelial markers. Adv Anatom Pathol 7:100-109, 2000.

Zarbo RJ, Prasad AR, Regezi JA, Gown AM, Savera AT. Salivary gland basal cell and canalicular adenomas: immunohistochemical demonstration of myoepithelial cell participation and morphogenetic considerations. Arch Pathol Lab Med 124:401-405, 2000.

Folpe A.L., Gown A.M., Lamps L.W., Garcia R., Dail D.H., Zarbo R.J., Schmidt R.A. Thyroid transcription factor-1: immunohistochemical evaluation in pulmonary neuroendocrine tumors. Mod Pathol 12: 5-8, 1999.

Jacobs T.W., Gown A.M., Yaziji H., Barnes M.J., Schnitt S.J. Comparison of fluorescence in situ hybridization and immunohistochemistry for the evaluation of HER2 in breast cancer. J Clin Oncol 17: 1974-1982. 1999.

Jacobs T.W., Gown A.M., Yaziji H., Barnes M.J., Schnitt S.J. Specificity of HercepTest™ in determining HER2 status of breast cancers using the United States Food and Drug Administration-approved scoring system. J Clin Oncol 17: 1983-1987, 1999.

Dr. Goldstein's Recent Publications

Haines, G.K. 3rd, Wiley, E., Susnik, B., Apple, S.K., Frkovic-Grazio, S., Reyes, C., Goldstein, L.C., Dadmanesh, F., Gown, A.M., Nadjj, M., Bracko, M., Tavassoli, F.A. HER2 in well differentiated breast cancer: is testing necessary? Breast Cancer Res Treat, 2008 (In Press).

Yaziji H, Goldstein LC, Barry TS, Werling R, Hwang H, Ellis GK, Gralow JR, Livingston RB, Gown AM. HER-2 testing in breast cancer using parallel tissue-based methods. JAMA 291: 1972-1977, 2004.

Gluck S, Ross AA, Layton TJ, Ostrander AB, Goldstein LC, Porter K, Ho AD. Decrease in tumor cell contamination and progenitor cell yield in leukopheresis products after consecutive cycles of chemotherapy for breast cancer treatment. Biol Blood Marrow Transplant 3:316-323, 1997.

Cabrian K, Shriver K, Goldstein L, Krieger M. Human immunodeficiency virus type 2: A review. J Clin Immunoassay 11:107-114, 1988.

Handsfield HH, Wandell M, Goldstein LC, Shriver K, and Cooperative Study Group. Screening and diagnostic performance of enzyme immunoassay for antibody to lymphadenopathy-associated virus. J Clin Micro 25:879-884, 1987.

Gosting LH, McClure J, Dickinson ES, Watanabe S, Shriver K, Goldstein LC. Monoclonal antibodies to gp110 and gp41 of human immunodeficiency virus. J Clin Micro 25:845-848, 1987.

Tenover FC, Edelstein PH, Goldstein LC, Sturge JC, Plorde JJ. Comparison of cross-staining reactions by Pseudomonas spp. and fluorescein-labeled polyclonal and monoclonal antibodies directed against Legionella pneumophila. J Clin Micro 23:647-649, 1986.

Peetoom F, Curry B, Dodd R, Fang CT, Goldstein L, Perkins H, Schneider G, Wandell M. Use of an enzyme immunoassay for detection of antibody to human immunodeficiency virus in low risk populations. Transfusion 26:536-538, 1986.

Edelstein PH, Beer KB, Sturge JC, Watson AJ, Goldstein LC. Clinical utility of a monoclonal direct fluorescent reagent specific for Legionella pneumophila: Comparative study with other reagents. J Clin Micro 22:419-421, 1985.

Tenover FC, Carlson L, Goldstein L, Sturge J, Plorde JJ. Confirmation of Legionella pneumophila cultures with a fluorescein labeled monoclonal antibody. J Clin Micro 21:983-984, 1985.

Hackman RC, Meyerson D, Meyers JD, Shulman HM, Sale GE, Goldstein LC, Rastetter M, Fluornoy N, Thomas ED. Rapid diagnosis of cytomegalovirus pneumonia by tissue immunofluorescence with a murine monoclonal antibody. J Inf Dis 151:325-329, 1985.

Gosting LH, Cabrian K, Sturge JC, Goldstein LC. Identification of a species specific antigen in Legionella pneumophila by a monoclonal antibody. J Clin Micro 20:1031-1035, 1984.

Goldstein LC, Corey L, McDougall JK, Tolentino E, Nowinski RC. Monoclonal antibodies to herpes simplex viruses: Use in antigenic typing and rapid diagnosis. J Infect Dis 147:829-837, 1983.

Nowinski RC, Tam MR, Goldstein LC, Stong L, Kuo C, Corey L, Stamm WE, Handsfield HH, Knapp JS, Holmes KK. Monoclonal antibodies for diagnosis of infectious diseases in humans. Science 219:637-644, 1983.

Peterson E, Schmidt OW, Goldstein LC, Nowinski RC, Corey L. Typing of clinical herpes simplex virus isolates with mouse monoclonal antibodies to herpes simplex virus types 1 and 2: Comparison with type-specific rabbit antisera and restriction endonuclease analysis of viral DNA. J Clin Micro 17:92-96, 1983.

Goldstein LC, McDougall J, Hackman R, Meyers JD, Thomas ED, Nowinski RC. Monoclonal antibodies to cytomegalovirus: Rapid identification of clinical isolates and preliminary use in diagnosis of cytomegalovirus pneumonia. Infect Immun 38:273-281, 1982.

Dr. Barry's Recent Publications

Vang R., Gown A.M., Barry T.S., Wheeler D.T., Ronnett B.M. Ovarian atypical proliferative (borderline) mucinous tumors:  gastrointestinal and seromucinous (endocervical-like) types are immunophenotypically distinctive. Int J Gynecol Pathol 25(1):83-89, 2006.

Terry J., Barry T.S., Horsman D.F., Hsu F.D., Gown A.M., Huntsman D.G., Nielsen T.O. Fluorescence in situ hybridization for the detection of t(X;18)(p11.2;q11.2) in a synovial sarcoma tissue microarray using a breakapart-style probe. Diagn Mol Pathol 14: 77-82, 2005.

Ng TL, Gown AM, Barry TS, Cheang MCU, Chan AKW, Turbin DA, Hsu FD, West RB, Nielsen TO. Nuclear beta-catenin in mesenchymal tumors. Modern Pathology 18:68-74, 2005.

Yaziji H, Goldstein LC, Barry TS, Werling R, Hwang H, Ellis GK, Gralow JR, Livingston RB, Gown AM. HER-2 testing in breast cancer using parallel tissue-based methods. JAMA 291: 1972-1977, 2004.

Barry TS, Jaffe ES, Sorbara L, Raffeld M, Pittaluga S. Peripheral T-cell lymphomas expressing CD30 and CD15. Am J Surg Pathol 27:1513-1522, 2003.

Nemets A, Ben Dor D, Barry TS, Ducach A, Blumental R, Ben Alon D, Lugassy G. Variant Richter's Syndrome: a rare case of classical Hodgkin's Lymphoma developing in a patient with chronic lymphocytic leukemia treated with fludarabine. Leuk Lymphoma 44:2151-2154, 2003.

Wiestner A, Rosenwald A, Barry TS, Wright G, Davis RE, Henrickson SE, Zhao H, Ibbotson RE, Orchard JA, Davis Z, Stetler-Stevenson M, Raffeld M, Arthur DC, Marti GE, Wilson WH, Hamblin TJ, Oscier DG, Staudt LM. ZAP-70 expression identifies a chronic lymphocytic leukemia subtype with unmutated immunoglobulin genes, inferior clinical outcome, and distinct gene expression profile. Blood 101:4944-4951, 2003. Epub 2003 Feb 20.

Barry TS, Jaffe ES, Kingma DW, Martin AW, Sorbara L, Raffeld M, Pittaluga S. CD5+ follicular lymphoma: a clinicopathologic study of three cases. Am J Clin Pathol 118:589-598, 2002.

Chen X, Scala G, Quinto I, Liu W, Chun TW, Justement JS, Cohen OJ, vanCott TC, Iwanicki M, Lewis MG, Greenhouse J, Barry T, Venzon D, Fauci AS. Protection of rhesus macaques against disease progression from pathogenic SHIV-89.6PD by vaccination with phage-displayed HIV-1 epitopes. Nat Med 7:1225-1231, 2001.

O'Malley DP, Opheim KE, Barry TS, Chapman DB, Emond MJ, Conrad EU, Norwood TH. Chromosomal changes in a dedifferentiated chondrosarcoma: a case report and review of the literature. Cancer Genet Cytogenet 124:105-111, 2001.

Rendt KE, Barry TS, Jones DM, Richter CB, McCachren SS, Haynes BF. Engraftment of human synovium into severe combined immune deficient mice. Migration of human peripheral blood T cells to engrafted human synovium and to mouse lymph nodes. J Immunol 151:7324-7336, 1993.

Barry TS, Haynes BF. In vivo models of human lymphopoiesis and autoimmunity in severe combined immune deficient mice. J Clin Immunol 12:311-324, 1992.

Barry TS, Jones DM, Richter CB, Haynes BF. Successful engraftment of human postnatal thymus in severe combined immune deficient (SCID) mice: differential engraftment of thymic components with irradiation versus antiasialo GM-1 immunosuppressive regimens. J Exp Med 173:167-180, 1991.

Miceli MC, Barry TS, Finn OJ. Human allograft-derived T-cell lines: donor class I- and class II-directed cytotoxicity and repertoire stability in sequential biopsies. Hum Immunol 22:185-198, 1988.

Miceli MC, Barry TS, Finn OJ. Human renal allograft infiltrating T cells: phenotype-function correlation and clonal heterogeneity. Transplant Proc 20:199-201, 1988.

Finn OJ, Miceli MC, Sanfilippo A, Bollinger RR, Barry TS. In vitro and in vivo human T cell repertoire in kidney allograft rejection. Transplant Proc 20:155-158, 1988.

Dr. Kandalaft's Recent Publications

Kim PM, Goldstein LC, Barry TS, Kussick SJ, Kandalaft PL, Gown AM. Extremely high concordance between immunohistochemistry and FISH testing for HER2 status using subtraction methodology scoring in breast cancer: a study of 5942 cases. Mod Pathol 2007 (In Press). (Platform presentation at the Annual Meeting of the United States and Canadian Academy of Pathology, San Diego, CA, March 2007)

Goldstein LC, Tirrell SE, Barry TS, Kussick SJ, Kandalaft PL, Kim PM, Gown AM. Immunophenotypic profile of the basal-like subtype of invasive breast carcinomas: influence on diagnosis and therapy. Mod Pathol 2007 (In Press). (Platform presentation at the Annual Meeting of the United States and Canadian Academy of Pathology, San Diego, CA, March 2007)

Barry TS, Kim PM, Treaba DO, Tirrell SE, Kussick SJ, Tse CH, Kandalaft PL, Gown AM. Use of p57KIP2 and Ki-67 immunohistochemistry and interphase FISH in the diagnosis of hydatidiform Mole: A unique algorithmic approach. Mod Pathol 2007 (In Press). (Platform presentation at the Annual Meeting of the United States and Canadian Academy of Pathology, San Diego, CA, March 2007)

Gown AM, Goldstein LC, Barry TS, Kussick SL, Kandalaft PL. Extremely high concordance between immunohistochemistry and FISH testing for HER-2/neu status in breast cancer: a study of 6720 cases. Breast Cancer Res Treat 100 (Supplement 1): S218, 2006. (Poster presentation at 29th Annual San Antonio Breast Cancer Symposium, San Antonio, TX, December 2006)

Tse CC, Treaba DO, Goldstein LC, Kandalaft PL, Barry TS, Gown AM. Sensitivity of immunohistochemical detection of EGFR could impact patient eligibility for anti-EGFR therapy. J Clin Oncol 23: 3607, 2005. (Poster presentation at the 2005 ASCO Annual Meeting, Orlando, FL, May 2005)

Treaba DO, Tse CC, Goldstein LC, Kandalaft PL, Barry TS, Gown AM. Influence of demographic and specimen related parameters on EGFR immunostaining in colorectal adenocarcinoma: A study of 484 cases. Mod Pathol 18(1): 120A, 2005. (Poster presentation at 94th Annual Meeting of the United States and Canadian Academy of Pathology, San Antonio, TX, February 2005)

Treaba DO, Hing AW, Tse CC, Goldstein LC, Barry TS, Kandalaft P, Gilks CB, Nielsen TO, Gown AM. Significantly improved sensitivity for ER detection in breast cancer using a new rabbit monoclonal anti-ER antibody (SP1). Mod Pathol 18(1): 53A, 2005. (Poster presentation at 94th Annual Meeting of the United States and Canadian Academy of Pathology, San Antonio, TX, February 2005)

Gown AM, Barry TS, Kandalaft P, Goldstein LC, Tse CC, Treaba DO. A new anti-ER rabbit monoclonal antibody improves efficiency of immunohistochemical evaluation of ER status in breast cancer. Mod Pathol 18(1): 35A, 2005. (Poster presentation at 94th Annual Meeting of the United States and Canadian Academy of Pathology, San Antonio, TX, February 2005)

Esteban JM, Kandalaft PL, Mehta P, Odom-Maryon TL, Bacus S, Battifora H. Improvement of the quantification of estrogen and progesterone receptors in paraffin-embedded tumors by image analysis. Am J Clin Pathol 99:32-38, 1993.

Arber DA, Kandalaft PL, Mehta P, Battifora H. Vimentin-negative epithelioid sarcoma. The value of an immunohistochemical panel that includes CD34. Am J Surg Pathol 17:302-307, 1993.

Kandalaft PL, Chang KL, Ahn CW, Traweek ST, Mehta P, Battifora H. Prognostic significance of immunohistochemical analysis of cathepsin D in low-stage breast cancer. Cancer 71:2756-2763, 1993.

Kandalaft PL, Esteban JM. Bilateral massive ovarian leiomyomata in a young woman: a case report with review of the literature. Mod Pathol 5:586-589, 1992 (Review).

Miller-Catchpole R, Shattuck M, Kandalaft P, Variakojis D, Anastasi J, Abrahams C. The incidence and distribution of Mycoplasma fermentans (incognitus strain) in the Chicago AIDS autopsy series: an immunohistochemical study. Chicago Associated Pathologists. Mod Pathol 4:481-486, 1991.

Traweek ST, Kandalaft PL, Mehta P, Battifora H. The human hematopoietic progenitor cell antigen (CD34) in vascular neoplasia. Am J Clin Pathol 96:25-31, 1991.

Toubbeh M, Kandalaft P, Wolff AP. Oncocytic cyst of the larynx. Ann Otol Rhinol Laryngol 98:240, 1989 (Abstract).

Dr. Kussick's Recent Publications

Kussick S.J. Multiparametric flow cytometry in the diagnosis of myelodysplastic syndromes and related disorders. Lab Med 38: 305-313, 2007.

Kussick S.J. Flow cytometry in the diagnosis of hematopoietic diseases. In Wintrobe’s Atlas of Clinical Hematology, ed. by D.C. Tkachuk and J.V. Hirschmann. Philadelphia, PA, Lippincott Williams & Wilkins, Chapter 6: 212-237, 2007.

Wood B.L., Arroz M., Barnett D., DiGiuseppe J., Greig B., Kussick S.J., Oldaker T., Shenkin M., Stone E., Wallace P. 2006 Bethesda International Consensus Recommendations on the immunophenotypic analysis of hematolymphoid neoplasia by flow cytometry: Optimal reagents and reporting for the flow cytometric diagnosis of hematopoietic neoplasia. Cytometry B Clin Cytom (In Press, 2007).

Fromm J.R., Kussick S.J., Wood B.L. Identification and purification of classical Hodgkin cells from lymph nodes by flow cytometry and flow cytometric cell sorting. Am J Clin Pathol 126: 764-780, 2006.

Kussick S.J., Fromm J.R., Rossini A., Li Y., Chang A., Norwood T.H., Wood B.L. Four-color flow cytometry shows strong concordance with bone marrow morphology and cytogenetics in the evaluation for myelodysplasia. Am J Clin Pathol 124: 170-181, 2005.

Nixon B.K., Kussick S.J., Carlon M.J., Rubin B.P. Intravascular large B-cell lymphoma involving hemangiomas: An unusual presentation of a rare neoplasm. Mod Pathol 18: 1121-1126, 2005.

Roberson R.S., Kussick S.J., Vallieres E., Chen S.Y., Wu D.Y. Escape from therapy-induced accelerated cellular senescence in p53 lung cancer cells and in human lung cancers. Cancer Research 65: 2795-2803, 2005.

Ahmed S., Kussick S.J., Siddiqui A.K., Bhuiya T.A., Khan A., Sarewitz S., Steinberg H., Sison C.P., Rai K.R. Bronchial–associated lymphoid tissue lymphoma: A clinical study of a rare disease. Eur J Cancer 40: 1320-1326, 2004.

Kussick S.J., Kalnoski M., Braziel R.M., Wood B.L. Prominent clonal B-cell populations identified by flow cytometry in histologically-reactive lymphoid proliferations. Am J Clin Pathol 121: 464-472, 2004.

Kussick S.J., Stirewalt D.L., Yi H.S., Sheets K.M., Pogosova-Agadjanyan E., Braswell S., Norwood T.H., Radich J.P., Wood B.L. A distinctive nuclear morphology in acute myeloid leukemia is strongly associated with loss of HLA-DR expression and FLT3 internal tandem duplication. Leukemia 18: 1591-1598, 2004.

Schmechel S.C., LeVasseur R.J., Yang K.H., Koehler K.M., Kussick S.J., Sabath D.E. Identification of genes whose expression patterns differ in benign lymphoid tissue and follicular, mantle cell, and small lymphocytic lymphoma. Leukemia 18: 841-855, 2004.

Stirewalt D.L., Meshinchi S., Kussick S.J., Sheets K.M., Pogosova-Agadjanyan E., Willman C.L., Radich J.P. Novel FLT3 point mutations within exon 14 found in patients with acute myeloid leukaemia. Br J Hematol 124: 481-484, 2004.

Chang A.C., Benda P.M., Wood B.L., Kussick S.J. Lineage-specific identification of nonhematopoietic neoplasms by flow cytometry. Am J Clin Pathol 119: 643-655, 2003.

Kussick S.J., Wood B.L. Using 4-color flow cytometry to identify abnormal myeloid populations. Arch Pathol Lab Med 127: 1140–1147, 2003.

Kussick S.J., Wood B.L. Four-color flow cytometry identifies virtually all cytogenetically abnormal bone marrow samples in the workup of non-CML myeloproliferative disorders. Am J Clin Pathol 120: 854-865, 2003.

Kussick S.J., Wood B.L., Sabath D.E. Mature T cell leukemias which cannot be adequately classified under the new WHO classification of lymphoid neoplasms. Leukemia 16: 2457-2458, 2002.

Christopher Tse's Recent Publications

Tse CC. Anatomic pathology image capture using a consumer-type digital camera. Am J Surg Pathol 23(12):1555-8, 1999.

Loo KT, Tsui WM, Chung KH, Ho LC, Tang SK, Tse CH. Hepatocellular carcinoma metastasizing to the brain and orbit: report of three cases. Pathology 26(2):119-22, 1994.

Lo YM, Lo ES, Mehal WZ, Sampietro M, Fiorelli G, Ronchi G, Tse CH, Fleming KA. Geographical variation in prevalence of hepatitis B virus DNA in HBsAg negative patients. J Clin Pathol 46(4):304-8, 1993.

Fung DT, Chan JK, Tse CC, Sze WM. Myxoid change in malignant lymphoma. Pathogenetic considerations. Arch Pathol Lab Med 116(1):103-5, 1992.

Tse CC, Chan JK, Yuen RW, Ng CS. Malignant lymphoma with myxoid stroma: a new pattern in need of recognition. Histopathology 18(1):31-5, 1991.

Chan JK, Tse CC. Solid cell nest-associated C-cells: another possible explanation for "C-cell hyperplasia" adjacent to follicular cell tumors. Hum Pathol 20(5):498-9, 1989.

Ng HK, Tse CC, Lo ST. Microcystic meningiomas--an unusual morphological variant of meningiomas. Histopathology 14(1):1-9, 1989.

Ng HK, Tse CC, Lo ST. Ependymomas--an immunohistochemical study of 14 cases. Histopathology 13(4):462-5, 1988.

Ng HK, Tse CC, Lo ST. Meningiomas and arachnoid cells: an immunohistochemical study of epithelial markers. Pathology 19(3):253-7, 1987.

Dr. Mukherjee's Recent Publications

Mukherjee S., Daifalla N., Zhang Y., Douglass J., Reed S.G., Campos-Neto A. Cloning of the Gene Encoding a Protective Mycobacterium tuberculosis Secreted Protein Detected In Vivo during the Initial Phases of the Infectious Process. J Immunol 175:5298-5305, 2005.

Mukherjee S., Daifalla N., Zhang Y., Douglass J., Brooks L., Vedvick T., Houghton R., Reed S.G., Campos-Neto A. Potential serological use of a recombinant protein that is a replica of a Mycobacterium tuberculosis protein found in the urine of infected mice. Clin Diagn Lab Immunol 11: 280–286, 2004.

Mukherjee S., Daifalla N., Liu C., Campos-Neto A. Alternative approach to express Mycobacterium tuberculosis proteins in Escherichia coli. Biotechniques 35: 34-36, 38, 40, 2003.

Adhya S., Hassan M.Q., Mukherjee S., Manna P.P., Basu A., Sen S., Bandyopadhyay S. Visceral leishmaniasis in India: promises and pitfalls of a PCR-based blood test. Trans R Soc Trop Med Hyg 96: S179-S183, 2002.

Mukherjee S., Petrofsky M., Yaraei K., Bermudez L.E., Cangelosi G.A. The white morphotype of Mycobacterium avium-intracellulare is common in infected humans and virulent in infection models. J Infect Dis 184: 1480-1484, 2001.

Ghosh S.S., Mukherjee S., Adhya S. Chromosome profile Leishmania donovani: interstrain and interspecific variations. J Biosci 23: 247-254, 1998.

Manna P.P., Basu A., Saha A., Hassan M.Q., Mukherjee S., Majumdar S., Adhya S., Bandyopadhyay S. Leishmania donovani infects lymphocyte cell lines in vitro. Current Science 73: 610-614, 1997.

Mukherjee S., Hassan M.Q., Ghosh A., Ghosh K.N., Bhattacharya A., Adhya S. Short Report: Leishmania DNA in Phlebotomus and Sergentomyia species during a kala-azar epidemic. Am J Tropic Med Hygiene 57: 423-425, 1997.

Adhya S., Chatterjee M., Hassan M.Q., Mukherjee S., Sen S. Detection of Leishmania in the blood of early kala-azar patients with the aid of the polymerase chain reaction. Trans R Soc Trop Med Hyg 89: 622-624, 1995.